Description
Product Parameters of Methotrexate CAS#59-05-2
1. Names and Identifiers
| Name | Methotrexate
|
| Synonyms
|
(+)-Amethopterin
4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid 4-Amino-N10-methylpteroylglutamic Acid EINECS 200-413-8 Hdmtx L-Amethopterin L-glutamic acid, N-(4-(((2,4-diamin0-6- pteridinyl)methyl)methylamino)benzoyl)- L-Glutamic acid, N-[4-[[(2,4-diamino-6- pteridinyl)methyl]methylamino]benzoyl]-(9Cl) METHOTREXATE(N-(4-(((2,4-DIAMINO-6- PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID) METHOTREXATEFORINJECTION MFCD00064370 N-(4-{[(2,4-Diamino-6-pteridinyl)methyl](methyl)amino}benzoyl)-L- glutamic acid |
2. Properties
| Density
|
1.536
|
| Melting point
|
195℃
|
| Boiling point | 561.26°C (rough estimate)
|
| Refractive index | 1.6910 (estimate)
|
| Flash Point
|
11℃
|
| Precise Quality
|
454.17100
|
| PSA
|
210.54000
|
| logP
|
1.82170
|
| Solubility
|
H2O: insoluble
|
| Appearance
|
yellow crystalline powder
|
| Storage
|
Store at -20°C. Hygroscopic. Light Sensitive.
|
| Color/Form
|
Pale-yellow to Yellow-brown Solid
|
|
Decomposition
|
When heated to decomposition it emits toxic fumes including /nitrogen oxides/.
|
| pKa | pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
|
| Water Solubility | Insoluble. |
| Spectral Properties
|
Specific optical rotation: 20.4 + or – 0.6 deg at 21 deg C/589 D (concentration by 0.1 N sodium hydroxide) maximum absorption: 243nm, A1= 388;307 nm, A1 = 475 (in 0.1 n hydrogen chloride). 258 nm, A1= 544; 303 nm, A1= 546; 372 nm, A1= 177 (in 0.1 N sodium hydroxide) UV max (0.1N HCl) 244, 307 nm; UV max (0.1N NaOH) 257, 302, 370 nm
|
| Stability | Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
|
| StorageTemp | −20°C |
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