Description
Nicotinamide Chemical Properties
| Melting point | 128-131 °C(lit.) |
| Boiling point | 150-160 °C |
| density | 1.40 |
| vapor density | 4.22 (vs air) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.4660 (estimate) |
| Fp | 182 °C |
| storage temp. | 2-8°C |
| solubility | 691g/l |
| pka | 3.3(at 20℃) |
| form | powder |
| color | white |
| PH | 6.0-7.5 (50g/l, H2O, 20℃) |
| Odor | Odorless |
| PH Range | 9 |
| Water Solubility | 1000 g/L (20 ºC) |
| Decomposition | >=200 °C |
| Merck | 14,6523 |
| BRN | 383619 |
| BCS Class | 1 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | DFPAKSUCGFBDDF-UHFFFAOYSA-N |
| LogP | -0.38 at 21℃ |
| CAS DataBase Reference | 98-92-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Niacinamide(98-92-0) |
| EPA Substance Registry System | Nicotinamide (98-92-0) |
Safety Information
| Hazard Codes | Xi,T,F |
| Risk Statements | 36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-37/39-45-36/37-16-7 |
| RIDADR | UN1230 – class 3 – PG 2 – Methanol, solution |
| WGK Germany | 1 |
| RTECS | QS3675000 |
| F | 8 |
| Autoignition Temperature | 480 °C |
| TSCA | Yes |
| HS Code | 29362990 |
| Hazardous Substances Data | 98-92-0(Hazardous Substances Data) |
| Toxicity | LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson) |
Product Application of Nicotinamide CAS#98-92-0
1. Moisturizing, oil control, and reducing blackheads Niacinamide can effectively reduce transepidermal water loss. Although the effect of using it alone is not as good as that of hyaluronic acid and glycerin, the effect of using it together is definitely 1+1>2; Niacinamide can calm down the sebaceous glands in an “excited” state, thereby achieving the effect of controlling oil and reducing blackheads and acne.
2. Good anti-wrinkle ability Niacinamide’s anti-wrinkle ability lies in its ability to activate ATP, provide vitality to keratinocytes, increase collagen synthesis, and has good synergistic ability, and can be used with other anti-wrinkle ingredients.
3. Good auxiliary sunscreen effect The harm caused by ultraviolet rays to the human body is not only tanning, but also leads to immunosuppression and even skin cancer. Many studies at home and abroad have shown that niacinamide can effectively reduce the occurrence of skin photoimmunosuppression during ultraviolet irradiation.
4. Good mildness Compared with ingredients such as vitamin C and resorcinol derivatives, niacinamide is quite mild, and many people’s skin types can basically use it, but you still need to pay attention to the problem of skin tolerance. For example, the 10% niacinamide concentration of The Ordinary whitening essence is still irritating. Therefore, it is best to undergo a skin tolerance test before use to confirm tolerance before starting use. At the same time, be careful not to use it with acid-containing products, such as salicylic acid and fruit acid, to prevent excessive irritation to the skin.
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